D. F. Brightwell, K. Samanta, J. A. Watts, M. W. Fay, A. Palma; Sequence-Controlled Divergent Supramolecular Assembly of Polyproline Helices into Metallo-Peptide Nanoparticles. Nanoscale Adv., 2025, 7, 94-98 DOI: 10.1039/D4NA00762J
D. F. Brightwell, K. Samanta, J. Muldoon, P. C. Fleming, Y. Ortin, L. Mardiana, P. G. Waddell, M. J. Hall, E. R. Clark, F. Fantuzzi, A. Palma; Applying Metallo-Organic Ligand Design Principles to the Stere-oselective Synthesis of a Peptide-Based Pd2L4X4 Cage. Chemistry Europe, 2024, DOI:10.1002/ceur.202400050 ;
Cover Feature (ChemistryEurope 1/2025)
The Cover Feature celebrates the stereoselective synthesis of a peptide-based palladium cage. The chiral, low-symmetry peptide-based ligand used to generate this Pd cage could theoretically yield up to four structural isomers. Remarkably, only a single isomeric cage is formed in solution, the thermodynamically stable one. The image represents the single isomer emerging into the spotlight from all the possible isomers, shown in different colours in the background. More information can be found in the Research Article by A. Palma and co-workers (DOI: 10.1002/ceur.202400050).
Brightwell D. F., Truccolo G., Samanta K., Shephered H. J., Palma A.; Supramolecular Self-Assembly of Engineered Polyproline Helices, ACS Macro Letters, 2023, DOI: 10.1021/acsmacrolett.3c00304
Brightwell D. F., Truccolo G., Samanta K., Fenn E. J., Holder S. J., Shephered H. J., Hawes C. S., Palma A.; A Reversibly Porous Supramolecular Peptide Framework, Chemistry – A European Journal, 2022,DOI:10.1002/chem.202202368.
Barrow S. J., Palma A., de Nijs B., Chikkaraddy R., Bowman R. W., Baumberg J. J. and Scherman O. A.; Nanometer control in plasmonic systems through discrete layer-by-layer macrocycle–cation deposition, Nanoscale, 2020, 12, 8706-8710. DOI: 10.1039/d0nr00902d.
Barrow S.J.; Assaf K.I.; Palma A.; Nau W.M.; Scherman O.A.; Preferential binding of unsaturated hydrocarbons in aryl-bisimidazolium· cucurbit [8] uril complexes furbishes evidence for small-molecule π–π interactions, Chemical Science, 2019, 10 (44), 10240-10246. DOI: 10.1039/C9SC03282G.
de Nijs B.; Benz F.; Barrow S. J.; Sigle D. O.; Chikkaraddy R.; Palma A.; Carnegie C.; Kamp M.; Sundararaman R.; Narang P.; Scherman O. A.; Baumberg J. J. Plasmonic tunnel junctions for single-molecule redox chemistry, Nature Communications, 2017, (8), pp 994-1001, DOI: 10.1038/s41467-017-00819-7.
Palma, A.; Artelsmair, M.; Wu, G.; Lu, X.; Barrow, S. J.; Uddin, N.; Rosta, E.; Masson E.; Scherman O. A. Cucurbit[7]uril as a Supramolecular Artificial Enzyme for Diels-Alder Reactions, Angew. Chem. Int. Ed., 2017, (56), pp 15688 –15692, DOI: 10.1002/anie.201706487.
Palma, A.; Groombridge, A. S.; Barrow, S. J.; Abell, C.; Scherman, O. A. Aqueous interfacial gels assembled from small molecule supramolecular polymers , Chem. Sci., 2017, (8), 1350-1355, DOI: 10.1039/C6SC04103E.
Kasera, S.; Sigle, D. O.; Herrman, L. O.; Palma, A.; de Nijs, B.; Benz, F.; Baumberg, J. J., Scherman, O. A. Observing Single Molecules Complexing with Cucurbit[7]uril through Nanogap-SERS J. Phys. Chem. Lett., 2016, (4), pp 704–710, DOI: 10.1021/acs.jpclett.5b02535.
Palma, A.; Serginson, J. M.; Barrett A. G. M. Synthesis of poly b-ketoesters via double acylketene trapping Tet. Lett. 2015, 56 (5), pp 674-676. DOI: 10.1016/j.tetlet.2014.12.036.
Grossi, M.; Palma A.; McDonnell, S. O.; Hall, M. J.; Rai, D. K.; Muldoon, J.; O’Shea, D. F. Mechanistic Insight into the Formation of Tetraarylazadipyrromethenes J. Org. Chem., 2012, 77 (20), pp 9304–9312. DOI: 10.1021/jo301972w.
Palma, A.; Alvarez, L. A.; Scholz, D.; Frimannsson, D. O.; Grossi, M.; Quinn, S. J. and O’Shea, D. F. Cellular Uptake Mediated Off/On Responsive Near-Infrared Fluorescent Nanoparticles J. Am. Chem. Soc., 2011, 133 (49), pp 19618–19621. DOI: 10.1021/ja208086e.
Batat, P.; Cantuel, M.; Jonusauskas, G.; Scarpantonio, L.; Palma, A.; O’Shea, D. F.; McClenaghan, N. D. BF2-Azadipyrromethenes: Probing the Excited-State Dynamics of a NIR Fluorophore and Photodynamic Therapy Agent J. Phys. Chem. A, 2011, 115 (48), pp 14034–14039. DOI: 10.1021/jp2077775.
Palma, A.; Tasior, M.; Frimannsson, D. O.; Vu, T. T.; Meallet-Renault, R.; O’Shea, D. F. New On-Bead Near-Infrared Fluorophores and Fluorescent Sensor Constructs Org. Lett. 2009, 11 (16), pp 3638-3641. DOI: 10.1021/ol901413u.
Palma, A.; Gallagher, J. F.; Mueller-Bunz, H.; Wolowska, J.; McInnes, E. J. L.; O’Shea, D. F. Co(II), Ni(II), Cu(II) and Zn(II) Complexes of Tetraphenylazadipyrromethene Dalton Trans. 2009, (2), pp 273-279. DOI: 10.1039/B811764K.
Loudet, A.; Bandichhor, R.; Burgess, K.; Palma, A.; McDonnell, S. O.; Hall, M. J.; O’Shea, D. F. B,O-Chelated Azadipyrromethenes as Near-IR Probes Org. Lett. 2008, 10 (21), pp 4771-4774. DOI: 10.1021/ol8018506.
Volpe, M. V.; Cimmino, A.; Pezzella, A.; Palma, A. Process for Synthesizing Halogenated Derivatives of Fluorescein for Use in the Production of Non-Volatile Memory Devices U.S. Pat. Appl. Publ. 2008, 15pp. Patent Number: US2008/61289.
Pezzella, A.; Palma, A.; Iadonisi, A.; Napolitano, A.; d’Ischia, M. The First Entry to 5,6-Dihydroxy-3-mercaptoindole, 5-Hydroxy-3-mercaptoindole and their 2-Carbomethoxy derivatives by a Mild Thiocyanation/Reduction Methodology Tet. Lett. 2007, 48 (22), pp 3883-3886. DOI: 10.1016/j.tetlet.2007.03.141.